GERK VA ME’DANING KISLOTAGA BOG’LIQ KASALLIKLARIDA SUTKALIK PH-IMPEDANSOMETRIYA VA SIRKAD BIOMARKERLARI NATIJALARI ORASIDAGI O’ZARO BOG’LIQLIKNI ILMIY ASOSLASH
Keywords:
Kalit so‘zlar: Gastroezofageal reflyuks kasalligi, kislotaga bog‘liq kasalliklar, sutkalik pH-impedansometriya, sirkad biomarkerlar, melatonin, kortizol, pepsinogen I/II, DeMeester indeksi, kronoterapiya.Abstract
Ushbu maqolada gastroezofageal reflyuks kasalligi (GERK) va me’daning kislotaga bog‘liq patologiyalari bo‘lgan bemorlarda sutkalik pH-impedansometriya ko‘rsatkichlari hamda sirkad biomarkerlar (melatonin, kortizol, Pepsinogen I/II va Gastrin-17) tebranish dinamikasi o‘rtasidagi patogenetik va korrelyatsion bog‘liqliklar ilmiy jihatdan asoslab berilgan. Tadqiqotda 110 nafar bemor va 20 nafar amaliy sog‘lom ko‘ngillilar tekshirildi. Olingan natijalar sirkad bioritmlar desinxroninozi (chronodisruption) va patologik reflyuks hamda kislota gipersekretsiyasi o‘rtasida kuchli korrelyatsion bog‘liqlik borligini isbotladi. Bu esa kislotaga bog‘liq kasalliklarni davolashda shaxsiylashtirilgan kronoterapiya yondashuvini qo‘llash uchun nazariy poydevor yaratadi.
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